Skin.
Personalized prescription protocols, physician-guided.
Acne Cream
Clindamycin · Tretinoin · Niacinamide, one cream.
$63/mo · billed every 3 months
Low-Dose Isotretinoin
A smaller daily dose over a longer course. Dispensed through iPLEDGE.
$199/mo
Tretinoin Cream
$33/mo · billed every 3 months
Isotretinoin
$229/mo
Spironolactone
$33/mo · billed every 3 months
Tranexamic Acid
$53/mo · billed every 3 months
- If a physician says no, you pay nothing.
- Your price never goes up.
- Ask your physician anything, messaging included.
ALL PROTOCOLS
Every skin formulation we offer.
Prescription creams, low-dose orals, and supporting care — all physician-prescribed, all filled by a US-licensed partner pharmacy.
Creams & gels
Oral systemic
Hormonal & pigmentation
HOW IT WORKS
Care, in three steps.
Choose your protocol
Select the protocol and dose suited to your goal.
Complete your intake
A licensed physician reviews your case and determines if treatment is appropriate.
Pharmacy delivery
Prepared by a US-licensed partner pharmacy. Delivered to your door on your plan's schedule.
FIND YOUR FIT
Which protocol fits you?
Prescription acne treatment at Happyglow runs from tretinoin and a compounded clindamycin-tretinoin-niacinamide cream to spironolactone, doxycycline and isotretinoin, including low-dose courses, with a physician choosing and adjusting the protocol. Isotretinoin is dispensed through iPLEDGE.
A physician confirms what fits from your intake.
| If this sounds like you | Often a fit | Good to know |
|---|---|---|
| Mild to moderate acne, first prescription | Tretinoin | Or Acne Compound Cream, a compounded cream that is not an FDA-approved finished product. |
| Hormonal, jawline acne in women | Spironolactone | Off-label for acne. |
| Inflamed acne needing a short course | Doxycycline | A 90-day course. |
| Stubborn or recurring acne after topicals | Low-Dose Isotretinoin | Dispensed through iPLEDGE. Never taken during pregnancy. |
| Severe nodular acne | Standard Isotretinoin | Dispensed through iPLEDGE. Never taken during pregnancy. |
| Melasma and dark spots | Oral Tranexamic Acid | Compounded, not an FDA-approved finished product. Or azelaic acid. |
FAQ
Common questions about acne treatment
Do you prescribe Accutane online?
Yes, when a physician finds it appropriate. Happyglow prescribes isotretinoin, the generic of Accutane, in standard and low-dose courses, dispensed through iPLEDGE from a US-licensed pharmacy.
Who is low-dose isotretinoin for?
Often people whose acne keeps coming back after topicals or antibiotics, or who want a gentler daily dose over a longer period. A lower daily dose is an off-label approach, and your physician decides from your intake whether it fits. Isotretinoin must never be taken during pregnancy.
How does iPLEDGE work with an online prescription?
iPLEDGE is the FDA-required safety program for isotretinoin. You, your physician and the pharmacy are all enrolled, and each month brings a check-in and any required tests before a new 30-day prescription is released. Happyglow's care team walks you through each step.
How long does tretinoin take?
Usually two to three months to see clearer skin. Dryness, peeling and a temporary flare can happen in the first weeks while your skin adjusts.
Can minors use Happyglow?
Yes. Happyglow treats patients under 18, including for acne, when a physician finds treatment appropriate.
Do you take insurance?
No. Happyglow never bills insurance. Every price is the full cash price, with the physician consult included. See every price on the pricing page.
Read: More on skin and acne
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